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Docutab 100mg 10 Caps, Doxyciclyne

Docutab 100mg 10 Caps, Doxyciclyne
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Docutab 100mg 10 Caps, Doxyciclyne

INDICATIONS: Doxycycline is indicated for infections caused by the following microorganisms: Rickettsiae fever Rocky Mountain spotted fever, typhus fever and typhus, Q fever Rickettsialpox and tick fever.

Mycoplasma pneumoniae (Eaton agent, PPLO). Chlamydia psittaci, formerly agent of psittacosis and ornithosis. Chlamydia trachomatis, lymphogranuloma venereum agent previously.

Doxycycline is indicated for the treatment of uncomplicated infections of the urethra, endocervix or rectum of adults due to Chlamydia trachomatis.

Calymmatobacterium (Donovania), granulomatosis (before inguinal granuloma agents). And B. Borrelia recurrentis Dutton, spirochetes responsible for relapsing fever transmitted by lice and ticks. Ureaplasma urealyticum (mycoplasma T), as agent and nongonococcal urethritis in men associated with infertility. Plasmodium falciparum (falciparum malaria resistant to chloroquine).

Doxycycline can be useful in case of acute intestinal amebiasis, along with amebicides management, also may be useful therapeutic adjunct in the treatment of severe acne.

Doxycycline is indicated in the treatment of trachoma, although the causal agent according to immunofluorescence tests, is not always eliminated.

Is indicated for the treatment of stage I of Lyme disease. Furthermore, it can be treated by inclusion conjunctivitis, either with single oral administration of doxycycline combining topical agents.

Doxycycline is indicated for prophylaxis in the following cases:

Typhus (Rickettsia tsutsugamushi).

Traveler's diarrhea (enterotoxigenic Escherichia coli).

Malaria (in areas where Plasmodium falciparum is resistant to chloroquine).

Pharmacokinetics in Humans: Doxycycline is a bacteriostatic for positive and negative rods and is believed to its antibacterial effect is that inhibits protein synthesis.

Tetracyclines are easily absorbed and fixed to plasma proteins to varying degrees. They are concentrated in the bile by the liver and excreted in urine and faeces in high concentrations and in biologically active form. Doxycycline is almost completely absorbed after oral administration.

The studies reported to date indicate that the absorption of doxycycline markedly unchanged by the ingestion of foods, including milk, unlike what is observed with some tetracyclines.

After normal adult volunteers administration of a 200 mg dose, serum levels reached a peak of 2.6 mcg / mL after 24 hours.The studies have shown no significant difference in the half life of doxycycline (range 18 to 22 hours) in patients with severely impaired renal function. Haemodialysis does not change the plasma half-life of doxycycline.

CONTRAINDICATIONS: Patients who have shown hypersensitivity to any of the tetracyclines.

PRECAUTIONS: As seen with other tetracyclines, doxycycline forms a stable calcium complex in any osteogenic tissue. We have seen a decrease in the fibula growth rate in infants receiving 25 mg / kg oral tetracycline every 6 hours. This reaction has been shown to be reversible when the drug discontinued.

The use of antibiotics may occasionally lead to the development of non-susceptible organisms. It is essential constant observation of the patient. If infection by resistant organisms, the antibiotic should be discontinued and appropriate therapy instituted measures.

When during the treatment of venereal diseases suspected syphilis coexist must be diagnostic procedures including darkfield examination. In all these cases, monthly serological tests should be performed at least four months.

In the long-term treatment should be performed periodic laboratory evaluations of organ systems, including hematopoietic studies, kidney and liver.

Photosensitivity has been observed in some individuals taking tetracyclines, as an exaggerated sunburn. Patients who for any reason are exposed to direct sunlight or ultraviolet radiation should be informed of this reaction by the use of tetracyclines, and the first evidence of skin erythema administration should be discontinued.

Antianabolic action of tetracyclines may lead to increased BUN. Studies done to date indicate that this does not happen when using doxycycline in patients with renal insufficiency.


Use in pregnancy: Not rated doxycycline in pregnant women, so it is not recommended for use during pregnancy.

Lactation: The tetracyclines pass into breast milk of nursing women, why they should be avoided in administration.

Use in children: The use of drugs of the tetracycline class during tooth development (last half of pregnancy, lactation and children up to 8 years of age) can lead to permanent discoloration of the teeth (yellow-gray-brown ). This undesirable reaction is more common with prolonged use, but has been observed following repeated short treatments. Have also been reported cases of enamel hypoplasia. Therefore, doxycycline not be used in the age groups mentioned above, unless other antibiotics unavailable, which if present is unlikely to be effective or, alternatively, are contraindicated.

ADVERSE REACTIONS: Because doxycycline absorption is essentially complete, gastrointestinal adverse effects are rare. We have observed the following side effects in patients receiving tetracyclines have.

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory processes of the anogenital region (with monilial growth).

Rarely reported liver dysfunction. These reactions have been observed with the administration of tetracyclines both orally and parenterally.

Have been reported rarely esophagitis and esophageal ulcers in patients receiving oral tetracycline. Most of these patients took the medication immediately before bedtime.

Skin: maculopapular and erythematous rash. Although rare, there have been reports of exfoliative dermatitis. Photosensitivity is discussed in section precautions.

Hypersensitivity reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

It is reported bulging fontanelles in infants and benign intracranial hypertension in adults who have received therapeutic doses. These effects rapidly disappear after discontinuing administration.

When administering any tetracycline for prolonged periods, it has been reported microscopic staining dark brown in the thyroid gland, but no disturbances were reported thyroid function.

DRUG INTERACTIONS AND OTHER GENDER: Because tetracyclines have been shown to decrease plasma prothrombin activity, patients who are receiving anticoagulant therapy may require adjustment, lowering the dose of the anticoagulant.

Since bacteriostatic drugs may interfere with the bactericidal effect of penicillin, doxycycline is not recommended and penicillin administered concomitantly.

Tetracyclines absorption is impaired by the aluminum containing antacids, calcium or magnesium, as well as iron and preparations containing bismuth salts.

Barbiturates, alcohol, carbamazepine and phenytoin decrease the half-life of doxycycline.


Renal toxicity: reported increased blood urea nitrogen when used tetracyclines apparently dose related.

Blood: There have been reports of hemolytic anemia, thrombocytopenia, and eosinophilia etropenia.

PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility: Results from animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues and can lead to toxic effects in it ( generally, in connection with skeletal developmental delays). There has also been evidence of embryotoxicity in animals treated early in pregnancy.

DOSAGE AND ADMINISTRATION: Treatment should be continued for at least 24 or 48 hours after the symptoms and fever have subsided. In case of streptococcal infections, treatment should be continued for 10 days, to prevent the development of rheumatic fever or glomerulonephritis.

The usual dose of doxycycline in adults is 200 mg on the first day of treatment (administered in one single dose or 2 doses of 100 mg every 12 hours), followed by a maintenance dose of 100 mg / day.

In the treatment of more severe infections (particularly chronic infections of the urinary tract) may be administered 200 mg daily during treatment.

Children over 8 years: The recommended dosage schedule for children weighing 50 kg or less is 4 mg / kg on the first day of treatment (in 1 or 2 doses). In more severe infections can be used up to 4 mg / kg daily. In children over 50 kg the recommended dose should be used for adults (see use in children).

Acne vulgaris: 50-100 mg daily for up to 12 weeks.

Uncomplicated gonococcal infections (except anorectal infections in men): 100 mg orally, 2 times a day for 7 days. As an alternative scheme of single dose 300 mg can be given away, and an hour later, another 300 mg. The medication should be given with food, including milk or carbonated beverages.

Infection urethral or rectal endocervical adult uncomplicated produced by Chlamydia trachomatis: 100 mg orally 2 times daily for a minimum of 10 days. If infections Ureaplasma urealyticum (mycoplasma T) in the male genital tract, the patient and her partner should be treated with 100 mg 2 times a day for 4 weeks.

Nongonococcal urethritis caused by Ureaplasma urealyticum: 100 mg orally two times a day for 7 days.

Primary and secondary syphilis: 300 mg daily, in divided doses for a minimum of 10 days.

Pelvic inflammatory disease in outpatients: It is recommended to apply 2 g cefoxitin intramuscularly or 3 g of amoxicillin or ampicillin 3.5 g orally or 4.8 million units of penicillin G procaine IM applied at two different sites, or ceftriaxone 250 mg IM Each of these schemes, except ceftriaxone must be accompanied by the oral administration of 1 g of prebenecid, followed by 100 mg of doxycycline orally 2 times daily for 10-14 days.

Falciparum malaria resistant to chloroquine: 200 mg daily for at least 7 days. There must be a fast acting schizontocidal as quinine, along with doxycycline. The recommended dose of quinine varies. Prophylaxis can be started 1-2 days before travel to malarious areas. Treatment should be continued during the trip and 4 weeks after leaving such areas.

Prophylaxis of malaria:

Adults: 100 mg daily.

Children over 8 years: 2 mg / kg per day with a maximum equal to the adult dose.

The louse-borne relapsing fever and tick and epidemic typhus have been successfully treated with a single oral dose of 100 or 200 mg, depending on its severity.

Selective prophylaxis and treatment of cholera in adults: 300 mg in a single dose.

Prevention of typhus: 200 mg as a single dose.

Prevention of traveler's diarrhea (Adults): 200 mg during the first day of travel (administered as a single dose or 100 mg every 12 hours), followed by 100 mg daily while in the risk area. No data exist on the prophylactic effect when using the antibiotic for more than 21 days.

Prevention of leptospirosis: 100 mg orally 2 times daily for 7 days.

Studies done to date have indicated that administration of doxycycline in usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal insufficiency.

Administration: Patients are advised to ingest sufficient quantities of liquid when under treatment with oral tetracycline drugs in order to reduce the possibility of irritation or ulceration of the esophagus. If gastric irritation occurs, it is recommended that doxycycline is ingested with food or milk. Studies indicate that the absorption of doxycycline is not significantly affected when ingested simultaneously with food.

MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION: The usual dose and frequency of administration of doxycycline differ from other tetracyclines. A recommended amounts in excess may result in increased frequency of side effects. No data from the prophylactic effect when using the antibiotic for more than 21 days.

In case of overdosage, discontinue medication, treat symptoms and institute supportive measures. Dialysis does not alter the serum half-life and therefore would not be beneficial in treating cases of overdosage.
Drug Name: Docutab
Comparative Brand: Vivradoxil
Active ingredient: Doxycycline
Presentation: Capsules
Concentration: 100 mg
Response time: No
Laboratory: Son's Laboratorios Quimica
Box of 10 capsules
Manufactured in: Mexico

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